2. Academic Validation
  3. Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes)

Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes)

  • J Nat Prod. 2011 Apr 25;74(4):603-8. doi: 10.1021/np100625a.
Patrick W Okanya 1,  Kathrin I Mohr,  Klaus Gerth,  Rolf Jansen,  Rolf Müller
Affiliations

Affiliation

  • 1 Helmholtz Centre for Infection Research, Work Group Microbial Drugs, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
PMID: 21456549 DOI: 10.1021/np100625a
Abstract

Marinoquinoline A (1) was isolated from the gliding bacterium Ohtaekwangia kribbensis together with the novel marinoquinolines B-F (2-6). Their structures were elucidated from NMR and HRESIMS data. The pyrroloquinolines showed weak Antibacterial and Antifungal activities and moderate cytotoxicity against four growing mammalian cell lines with IC(50) values ranging from 0.3 to 8.0 μg/mL. In a screening against tropical parasites marinoquinolines A-F (1-6) showed activity against Plasmodium falciparum K1 with IC(50) values between 1.7 and 15 μM.

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