2. Academic Validation
  3. Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus

Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus

  • Bioorg Med Chem. 2011 May 15;19(10):3120-7. doi: 10.1016/j.bmc.2011.04.004.
Shi-Jin Qu 1,  Gui-Feng Wang,  Wen-Hu Duan,  Shan-Yan Yao,  Jian-Ping Zuo,  Chang-Heng Tan,  Da-Yuan Zhu
Affiliations

Affiliation

  • 1 Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.
PMID: 21524588 DOI: 10.1016/j.bmc.2011.04.004
Abstract

A series of tryptamine derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent Antiviral activity (IC(50)=0.4 and <1 μM, respectively) and low cytotoxicity (CC(50)=40.6 and >25 μM, respectively).

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z