2. Academic Validation
  3. Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala

Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala

  • J Nat Prod. 2011 May 27;74(5):1230-5. doi: 10.1021/np200164k.
Hanxiang Li 1,  Hongbo Huang,  Changlun Shao,  Huarong Huang,  Jieyi Jiang,  Xun Zhu,  Yayue Liu,  Lan Liu,  Yongjun Lu,  Mengfeng Li,  Yongcheng Lin,  Zhigang She
Affiliations

Affiliation

  • 1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
PMID: 21545109 DOI: 10.1021/np200164k
Abstract

Four new norsesquiterpene peroxides, named talaperoxides A-D (1-4), as well as one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by 1D and 2D NMR. Structures of 1, 2, and 5 were further confirmed by single-crystal X-ray diffraction, and their absolute configurations were also determined using copper radiation. Cytotoxic activities of compounds 1-5 were evaluated in vitro against human Cancer cell lines MCF-7, MDA-MB-435, HepG2, HeLa, and PC-3. Compounds 2 and 4 showed cytotoxicity against the five human Cancer cell lines with IC50 values between 0.70 and 2.78 μg/mL.

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