2. Academic Validation
  3. Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors

Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors

  • Bioorg Med Chem Lett. 2011 Jun 15;21(12):3774-9. doi: 10.1016/j.bmcl.2011.04.053.
Xiaohui Du 1,  Mike Lizarzaburu,  Simon Turcotte,  Taeweon Lee,  Joanne Greenberg,  Bei Shan,  Peter Fan,  Yun Ling,  Julio C Medina,  Jonathan Houze
Affiliations

Affiliation

  • 1 Amgen Inc., South San Francisco, CA 94080, USA. xdu@amgen.com
PMID: 21565497 DOI: 10.1016/j.bmcl.2011.04.053
Abstract

Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 Inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties of this series of SGLT2 inhibitors. From these efforts, compounds 28 and 32 have improved solubility and pharmacokinetic properties compared to compound 1.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z