2. Academic Validation
  3. Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B

Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B

  • Bioorg Med Chem Lett. 2011 Aug 15;21(16):4865-8. doi: 10.1016/j.bmcl.2011.06.026.
Mari Kikuchi 1,  Yoshihisa Watanabe,  Masaki Tanaka,  Kenichi Akaji,  Hiroyuki Konno
Affiliations

Affiliation

  • 1 Department of Biochemical Engineering, Graduate School of Science and Technology, Yamagata University, Yonezawa, Yamagata 992-8510, Japan.
PMID: 21741837 DOI: 10.1016/j.bmcl.2011.06.026
Abstract

Solid phase synthesis of the cyclic depsipeptides of callipeltin B analogues and evaluation of cytotoxicity of synthetic Peptides are described. We attempted to synthesize cyclic depsipeptides via the esterification or the amide bond formation for cyclization steps. In the assay of synthetic Peptides, the linear peptide (10) exhibited modest cytotoxicity against HeLa cells.

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