2. Academic Validation
  3. Swerilactones L-O, secoiridoids with C₁₂ and C₁₃ skeletons from Swertia mileensis

Swerilactones L-O, secoiridoids with C₁₂ and C₁₃ skeletons from Swertia mileensis

  • J Nat Prod. 2011 Aug 26;74(8):1822-5. doi: 10.1021/np200256b.
Chang-An Geng 1,  Xue-Mei Zhang,  Yun-Bao Ma,  Jie Luo,  Ji-Jun Chen
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, People's Republic of China.
PMID: 21823575 DOI: 10.1021/np200256b
Abstract

Swerilactones L-O (1-4), four unusual secoiridoids with unprecedented C₁₂ and C₁₃ skeletons, were isolated from the traditional Chinese herb Swertia mileensis. Compounds 1 and 2 had moderate inhibitory activities against the secretion of hepatitis B virus surface antigen (IC₅₀ = 1.47 and 1.20 mM, with SI < 1 and 1.53, respectively) and hepatitis B virus e antigen (IC₅₀ = 0.88 and >2.69 mM, with SI 1.62 and <1, respectively) in an antihepatitis B virus assay on the Hep G 2.2.15 cell line in vitro.

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