2. Academic Validation
  3. Monanchocidins B-E: polycyclic guanidine alkaloids with potent antileukemic activities from the sponge Monanchora pulchra

Monanchocidins B-E: polycyclic guanidine alkaloids with potent antileukemic activities from the sponge Monanchora pulchra

  • J Nat Prod. 2011 Sep 23;74(9):1952-8. doi: 10.1021/np200452m.
Tatyana N Makarieva 1,  Ksenya M Tabakmaher,  Alla G Guzii,  Vladimir A Denisenko,  Pavel S Dmitrenok,  Larisa K Shubina,  Alexandra S Kuzmich,  Hyi-Seung Lee,  Valentin A Stonik
Affiliations

Affiliation

  • 1 Laboratory of MaNaPro Chemistry, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok-22, Russian Federation. makarieva@piboc.dvo.ru
PMID: 21848268 DOI: 10.1021/np200452m
Abstract

New unusual polycyclic guanidine Alkaloids monanchocidins B-E (2-5) along with monanchocidin A (1), which we recently described, were isolated from the Far-Eastern marine Sponge Monanchora pulchra. Their structures were established using spectroscopic data and chemical transformations. Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 540, 200, 110, 830, and 650 nM, respectively.

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