2. Academic Validation
  3. Neuraminidase inhibitory polyketides from the marine-derived fungus Phoma herbarum

Neuraminidase inhibitory polyketides from the marine-derived fungus Phoma herbarum

  • Planta Med. 2012 Jan;78(1):76-8. doi: 10.1055/s-0031-1280251.
Gao Fei Zhang 1,  Wen Bo Han,  Jiang Tao Cui,  Seik Weng Ng,  Zhi Kai Guo,  Ren Xiang Tan,  Hui Ming Ge
Affiliations

Affiliation

  • 1 Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
PMID: 21969116 DOI: 10.1055/s-0031-1280251
Abstract

Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.15 to 9.16 µM.

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