2. Academic Validation
  3. Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

  • Bioorg Med Chem Lett. 2011 Nov 15;21(22):6884-7. doi: 10.1016/j.bmcl.2011.09.021.
To Dao Cuong 1,  Tran Manh Hung,  MinKyun Na,  Do Thi Ha,  Jin Cheol Kim,  Dongho Lee,  SungWoo Ryoo,  Jeong Hyung Lee,  Jae Sue Choi,  Byung Sun Min
Affiliations

Affiliation

  • 1 College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
PMID: 21978676 DOI: 10.1016/j.bmcl.2011.09.021
Abstract

Three new phenolics: ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'-(4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

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