2. Academic Validation
  3. Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation

Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation

  • Org Lett. 2011 Dec 2;13(23):6280-3. doi: 10.1021/ol202760c.
Yusuke Kobayashi 1,  Mami Kuroda,  Natsuki Toba,  Mari Okada,  Rie Tanaka,  Tetsutaro Kimachi
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyubancho, Nishinomiya 663-8179, Hyogo, Japan. ykoba@mukogawa-u.ac.jp
PMID: 22066966 DOI: 10.1021/ol202760c
Abstract

An efficient method for constructing quinoxalinone-N-oxides from cyanoacetanilides has been developed. This transformation can be achieved using inexpensive reagents and molecular oxygen under mild conditions, thus offering a practical pathway to quinoxalinone-containing pharmaceuticals such as ataquimast and opaviraline.

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