2. Academic Validation
  3. Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs

Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs

  • Bioorg Med Chem Lett. 2012 Jan 1;22(1):431-5. doi: 10.1016/j.bmcl.2011.10.112.
Ajay Kumar 1,  Bhahwal A Shah,  Samar Singh,  Abid Hamid,  Shashank K Singh,  Vijay K Sethi,  Ajit K Saxena,  Jaswant Singh,  Subhash C Taneja
Affiliations

Affiliation

  • 1 Natural Product Microbes Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180 001, India.
PMID: 22123322 DOI: 10.1016/j.bmcl.2011.10.112
Abstract

Boswellic acid acylates including their epimers were synthesized and screened against a panel of human Cancer cell lines. They exhibited a range of cytotoxicity against various human Cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential Anticancer lead.

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