2. Academic Validation
  3. Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest

Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest

  • J Nat Prod. 2012 Mar 23;75(3):479-83. doi: 10.1021/np200697j.
Yumin Dai 1,  Liva Harinantenaina,  Peggy J Brodie,  Martin W Callmander,  Richard Randrianaivo,  Stephan Rakotonandrasana,  Etienne Rakotobe,  Vincent E Rasamison,  Yongchun Shen,  Karen TenDyke,  Edward M Suh,  David G I Kingston
Affiliations

Affiliation

  • 1 Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
PMID: 22136523 DOI: 10.1021/np200697j
Abstract

Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian Cancer cell line led to the isolation of two new acetogenins. The structures of these two compounds were elucidated on the basis of analysis of their 1D and 2D NMR spectra, circular dichroism, and mass spectrometric data, together with chemical modification. The two acetogenins display weak antiproliferative activity against the A2780 ovarian Cancer, the A2058 melanoma, and the H522 lung Cancer cell lines.

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