2. Academic Validation
  3. Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation

Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation

  • Bioorg Med Chem Lett. 2012 Jan 15;22(2):1125-9. doi: 10.1016/j.bmcl.2011.11.103.
Chiara Brullo 1,  Massimo Rocca,  Paola Fossa,  Elena Cichero,  Elisabetta Barocelli,  Vigilio Ballabeni,  Lisa Flammini,  Carmine Giorgio,  Francesca Saccani,  Giuseppe Domenichini,  Olga Bruno
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Farmaceutiche, University of Genoa, V.le Benedetto XV, 3-16132 Genova, Italy.
PMID: 22189137 DOI: 10.1016/j.bmcl.2011.11.103
Abstract

In pursuing our research on some 2,4-diamino-benzopyranopyrimidines and 2-amino-5,6-dihydrobenzo[h]quinazolines, previously reported as antiplatelet and analgesic/anti-inflammatory agents respectively, we designed and synthesized a new series of 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted. The insertion of amino substituents at positions 2 and 4 of the benzoquinazoline scaffold resulted in compounds endowed with a potent ASA-like antiplatelet activity, combined with an anti-inflammatory activity comparable, in some cases, to that of indomethacin, used as a reference drug.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z