2. Academic Validation
  3. 1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents

1,2,4-Oxadiazoles: a new class of anti-prostate cancer agents

  • Bioorg Med Chem Lett. 2012 Mar 1;22(5):1912-6. doi: 10.1016/j.bmcl.2012.01.059.
Gopal L Khatik 1,  Jasmine Kaur,  Varun Kumar,  Kulbhushan Tikoo,  Vipin A Nair
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab 160 062, India.
PMID: 22326399 DOI: 10.1016/j.bmcl.2012.01.059
Abstract

Sulfide and sulfonyl derivatives of 1,2,4-oxadiazoles were synthesized and screened by MTT assay on the prostate Cancer cells, DU-145. Six compounds were identified as potential anti-prostate Cancer agents with IC(50) values ranging from 0.5 to 5.1μM. These compounds exhibited good activity on the androgen independent cells PC-3, while the results were moderate on androgen dependent LNCaP cells, suggesting the possibility of a mechanism of action different from that of the bioisosteric bicalutamide. Also a very low cytotoxicity was observed on non-cancerous cells MCF-10A.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z