2. Academic Validation
  3. Design, synthesis, and biological action of 20R-hydroxyvitamin D3

Design, synthesis, and biological action of 20R-hydroxyvitamin D3

  • J Med Chem. 2012 Apr 12;55(7):3573-7. doi: 10.1021/jm201478e.
Yan Lu 1,  Jianjun Chen,  Zorica Janjetovic,  Phillip Michaels,  Edith K Y Tang,  Jin Wang,  Robert C Tuckey,  Andrzej T Slominski,  Wei Li,  Duane D Miller
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
PMID: 22404326 DOI: 10.1021/jm201478e
Abstract

The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies.

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