2. Academic Validation
  3. Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy

Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy

  • Eur J Med Chem. 2012 Jun:52:33-43. doi: 10.1016/j.ejmech.2012.03.002.
Ming-Ming Liu 1,  Lu Zhou,  Pei-Lan He,  Yi-Nan Zhang,  Jia-Yi Zhou,  Qing Shen,  Xin-Wen Chen,  Jian-Ping Zuo,  Wei Li,  De-Yong Ye
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, China.
PMID: 22445328 DOI: 10.1016/j.ejmech.2012.03.002
Abstract

Common feature based pharmacophore and structure-based docking approaches have been employed in the identification of novel anti-HCV candidates from our in-house database. A total of 31 hits identified in silico were screened in vitro assay. 20 Compounds demonstrated anti-HCV activities (EC(50)<50 μM), including two naturally occurring Flavones apigenin (21) and luteolin (22) with low micromole EC(50) values and three compounds (23, 24 and 25) of novel scaffolds with moderate potencies. In addition, pharmacophore refinement was also conducted based on the current knowledge of flavone-derived anti-HCV candidates and the results of combined in silico and in vitro assays.

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