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  3. Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana

  • Bioorg Med Chem Lett. 2012 Apr 15;22(8):2927-31. doi: 10.1016/j.bmcl.2012.02.047.
Jin Woo Lee 1,  Cheong-Yong Yun,  Eunmiri Roh,  Chul Lee,  Qinghao Jin,  Kwon Ki Bang,  Sang-Hun Jung,  Dongho Lee,  Mi Kyeong Lee,  Youngsoo Kim,  Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
PMID: 22450129 DOI: 10.1016/j.bmcl.2012.02.047
Abstract

Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

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