2. Academic Validation
  3. Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

  • Bioorg Med Chem Lett. 2012 Jun 1;22(11):3653-5. doi: 10.1016/j.bmcl.2012.04.033.
Eonjeong Park 1,  Yoon Jung Yang,  Aejin Kim,  Jong Hwan Kwak,  Young Hoon Jung,  Se Chan Kang,  In Su Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
PMID: 22543029 DOI: 10.1016/j.bmcl.2012.04.033
Abstract

The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC(50) values of 18.3 and 17.9 μM, respectively.

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