2. Academic Validation
  3. Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors

  • Bioorg Med Chem Lett. 2012 Jun 15;22(12):4127-32. doi: 10.1016/j.bmcl.2012.04.065.
Aesop Cho 1,  Lijun Zhang,  Jie Xu,  Darius Babusis,  Thomas Butler,  Rick Lee,  Oliver L Saunders,  Ting Wang,  Jay Parrish,  Jason Perry,  Joy Y Feng,  Adrian S Ray,  Choung U Kim
Affiliations

Affiliation

  • 1 Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94044, USA. acho@gilead.com
PMID: 22578461 DOI: 10.1016/j.bmcl.2012.04.065
Abstract

A series of 2'-C-methyl branched purine and pyrimidine C-nucleosides were prepared. Their anti-HCV activity and pharmacological properties were profiled, and compared with known 2'-C-Me N-nucleoside counterparts. In particular, 2'-C-Me 4-aza-7,9-dideazaadenosine C-nucleoside (2) was found to have potent and selective anti-HCV activity in vitro as well as a favorable pharmacokinetic profile and in vivo potential for enhanced potency over the corresponding N-nucleoside.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z