2. Academic Validation
  3. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions

BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions

  • Cell. 2012 May 11;149(4):871-85. doi: 10.1016/j.cell.2012.02.066.
Andrew J Whittle 1,  Stefania Carobbio,  Luís Martins,  Marc Slawik,  Elayne Hondares,  María Jesús Vázquez,  Donald Morgan,  Robert I Csikasz,  Rosalía Gallego,  Sergio Rodriguez-Cuenca,  Martin Dale,  Samuel Virtue,  Francesc Villarroya,  Barbara Cannon,  Kamal Rahmouni,  Miguel López,  Antonio Vidal-Puig
Affiliations

Affiliation

  • 1 Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, UK. ajw232@cam.ac.uk
PMID: 22579288 DOI: 10.1016/j.cell.2012.02.066
Abstract

Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, here, we describe a role for BMP8B in the direct regulation of thermogenesis. BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased Lipase activity. Bmp8b(-/-) mice exhibit impaired thermogenesis and reduced metabolic rate, causing weight gain despite hypophagia. BMP8B is also expressed in the hypothalamus, and Bmp8b(-/-) mice display altered neuropeptide levels and reduced phosphorylation of AMP-activated protein kinase (AMPK), indicating an anorexigenic state. Central BMP8B treatment increased sympathetic activation of BAT, dependent on the status of AMPK in key hypothalamic nuclei. Our results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK. BMP8B may offer a mechanism to specifically increase energy dissipation by BAT.

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