2. Academic Validation
  3. Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents

Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents

  • Eur J Med Chem. 2012 Aug:54:669-78. doi: 10.1016/j.ejmech.2012.06.015.
René Csuk 1,  Sabrina Albert,  Bianka Siewert,  Stefan Schwarz
Affiliations

Affiliation

  • 1 Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. rene.csuk@chemie.uni-halle.de
PMID: 22749392 DOI: 10.1016/j.ejmech.2012.06.015
Abstract

Several new (E) Stilbenes were synthesized by a combination of a Wittig olefination followed by Mizoroki-Heck coupling reactions. These compounds were screened for antitumor activity in a panel of 8 human Cancer cell lines by a colorimetric SRB assay. Several of these compounds exhibit strong cytotoxicity. The most active compound of this series showed an average IC(50) value of 0.03 μmol; it acts by Apoptosis as shown by a dye-exclusion test, an extra acridine orange/ethidium bromide staining and DNA-laddering experiments.

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