2. Academic Validation
  3. Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone

Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone

  • Bioorg Med Chem Lett. 2012 Oct 1;22(19):6144-7. doi: 10.1016/j.bmcl.2012.08.023.
Nigel S Simpkins 1,  Frank Holtrup,  Vincent Rodeschini,  James D Taylor,  Robert Wolf
Affiliations

Affiliation

  • 1 School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. n.simpkins@bham.ac.uk
PMID: 22944119 DOI: 10.1016/j.bmcl.2012.08.023
Abstract

The synthesis of an unnatural polyprenylated acylphloroglucinol (PPAP), regioisomeric with nemorosone and clusianone, has been accomplished. The separated enantiomers of this new PPAP, along with those of nemorosone and clusianone, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) Cancer cell lines. All of the isomers examined gave surprisingly similar results in the screens.

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