2. Academic Validation
  3. Sesquiterpenes from the aerial part of Chloranthus japonicus and their cytotoxicities

Sesquiterpenes from the aerial part of Chloranthus japonicus and their cytotoxicities

  • Fitoterapia. 2012 Dec;83(8):1604-9. doi: 10.1016/j.fitote.2012.09.009.
Mi Zhang 1,  Jun-Song Wang,  Peng-Ran Wang,  Masayoshi Oyama,  Jun Luo,  Tetsuro Ito,  Munekazu Iinuma,  Ling-Yi Kong
Affiliations

Affiliation

  • 1 State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.
PMID: 22986292 DOI: 10.1016/j.fitote.2012.09.009
Abstract

Four new Sesquiterpenes, chlorajapolides F-I (1-4), along with nine known Terpenoids (5-13) were isolated from the aerial part of Chloranthus japonicus. Their structures were elucidated on the basis of spectroscopic analysis, and a lindenane sesquiterpene, named 9-hydroxy-heterogorgiolide, previously isolated from the C. japonicus, was revised as its 8-epimer (1a). Moreover, methanol extract (ME), EtOAc fraction (EF), water fraction (WF), and all isolates (1a, 1-13) were evaluated for their cytotoxicities using two human Cancer cell lines.

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