2. Academic Validation
  3. Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules

Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules

  • J Med Chem. 2012 Oct 25;55(20):8969-73. doi: 10.1021/jm3012189.
Laxman Pokhrel 1,  Izumi Maezawa,  Thi D T Nguyen,  Kyeong-Ok Chang,  Lee-Way Jin,  Duy H Hua
Affiliations

Affiliation

  • 1 Department of Chemistry, 213 CBC Building, Kansas State University, Manhattan, Kansas 66503, USA.
PMID: 23025824 DOI: 10.1021/jm3012189
Abstract

A major effort in Alzheimer's disease therapeutic development has targeted Aβ and downstream events. We have synthesized a small library of tricyclic pyrone compounds. Their protective action in MC65 cells and inhibition of ACAT along with the upregulation of Cholesterol transporter gene were investigated. Five active compounds exhibited potencies in the nanomolar ranges. The multiple effects of the compounds on Aβ and cellular Cholesterol pathways could be potential mechanisms underlying the protective effects in vivo.

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