2. Academic Validation
  3. Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent

Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent

  • Eur J Med Chem. 2013 Feb:60:120-7. doi: 10.1016/j.ejmech.2012.11.044.
Koneni V Sashidhara 1,  Srinivasa Rao Avula,  Komal Sharma,  Gopala Reddy Palnati,  Surendar Reddy Bathula
Affiliations

Affiliation

  • 1 Department of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India. sashidhar123@gmail.com
PMID: 23287057 DOI: 10.1016/j.ejmech.2012.11.044
Abstract

Development of new, targeted antibreast Cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast Cancer agent which selectively induce Apoptosis in both primary and metastatic breast Cancer cell lines.

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