2. Academic Validation
  3. Aryl azide photochemistry in defined protein environments

Aryl azide photochemistry in defined protein environments

  • Org Lett. 2013 Feb 15;15(4):728-31. doi: 10.1021/ol3028779.
Josephine L Morris 1,  Samuel C Reddington,  Damien M Murphy,  D Dafydd Jones,  James A Platts,  Eric M Tippmann
Affiliations

Affiliation

  • 1 School of Chemistry, Cardiff University, Cardiff CF10 3AT United Kingdom.
PMID: 23351055 DOI: 10.1021/ol3028779
Abstract

A genetically encoded precursor to an aryl nitrene, para-azidophenylalanine, was introduced site specifically into proteins to deduce if distinct environments were capable of caging a reactive organic intermediate. Following photolysis of mutant T4 lysozyme or green fluorescent proteins, EPR spectra showed, respectively, the presence of a triplet nitrene and an anilino radical.

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