2. Academic Validation
  3. Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

  • Bioorg Med Chem Lett. 2013 Mar 15;23(6):1823-7. doi: 10.1016/j.bmcl.2013.01.032.
Nguyen Phuong Thao 1,  Le Duc Dat,  Ninh Thi Ngoc,  Vu Anh Tu,  Tran Thi Hong Hanh,  Phan Thi Thanh Huong,  Nguyen Xuan Nhiem,  Bui Huu Tai,  Nguyen Xuan Cuong,  Nguyen Hoai Nam,  Pham Van Cuong,  Seo Young Yang,  Sohyun Kim,  Doobyeong Chae,  Young-Sang Koh,  Phan Van Kiem,  Chau Van Minh,  Young Ho Kim
Affiliations

Affiliation

  • 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam; College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
PMID: 23395633 DOI: 10.1016/j.bmcl.2013.01.032
Abstract

Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8μM, respectively.

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