2. Academic Validation
  3. Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives

Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives

  • Bioorg Med Chem Lett. 2013 Mar 15;23(6):1846-52. doi: 10.1016/j.bmcl.2013.01.022.
Manochehr Shahabi 1,  Eva Schirmer,  Karem Shanab,  Theerachart Leepasert,  Jana Ruzicka,  Wolfgang Holzer,  Helmut Spreitzer,  Babette Aicher,  Peter Schmidt,  Lars Blumenstein,  Gilbert Müller,  Eckhard Günther
Affiliations

Affiliation

  • 1 Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
PMID: 23395656 DOI: 10.1016/j.bmcl.2013.01.022
Abstract

A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung Cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested.

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