2. Academic Validation
  3. Xanthoquinodins from the endolichenic fungal strain Chaetomium elatum

Xanthoquinodins from the endolichenic fungal strain Chaetomium elatum

  • J Nat Prod. 2013 Apr 26;76(4):702-9. doi: 10.1021/np400041y.
Guo-Dong Chen 1,  Ying Chen,  Hao Gao,  Li-Qing Shen,  Yang Wu,  Xiao-Xia Li,  Yan Li,  Liang-Dong Guo,  Ying-Zhou Cen,  Xin-Sheng Yao
Affiliations

Affiliation

  • 1 Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
PMID: 23586920 DOI: 10.1021/np400041y
Abstract

Five new xanthoquinodins, A4-A6 (1-3), B4 (4), and B5 (5), were isolated from the crude extract of the endolichenic Fungal strain Chaetomium elatum (No. 63-10-3-1), along with three known xanthoquinodins, A1-A3 (6-8). Their structures were determined by detailed spectroscopic analysis and comparison of the NMR data with those of the closely related compounds previously reported. The absolute configuration of 1 was established by X-ray crystallographic analysis and ECD calculation. The cytotoxic activity of all compounds was tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human Cancer cell lines.

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