2. Academic Validation
  3. Design, synthesis and biological studies of novel tubulin inhibitors

Design, synthesis and biological studies of novel tubulin inhibitors

  • Bioorg Med Chem Lett. 2013 Aug 1;23(15):4465-8. doi: 10.1016/j.bmcl.2013.04.078.
Yanjun Sun 1,  Bulbul Pandit,  Somsundaram N Chettiar,  Jonathan P Etter,  Andrew Lewis,  Jayasekar Johnsamuel,  Pui-Kai Li
Affiliations

Affiliation

  • 1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 338 Parks Hall, 500 West 12th Avenue, Columbus, OH 43210-1291, United States.
PMID: 23790539 DOI: 10.1016/j.bmcl.2013.04.078
Abstract

A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, were synthesized and evaluated. The most potent compound in this series, compound 3, which structurally resembles the potent anti-microtubule agent combretastatin A-4, inhibited tubulin polymerization and showed potent growth inhibitory activities on both prostate and breast Cancer lines with IC50 values in the low nanomolar range.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z