2. Academic Validation
  3. Vialinin A is a ubiquitin-specific peptidase inhibitor

Vialinin A is a ubiquitin-specific peptidase inhibitor

  • Bioorg Med Chem Lett. 2013 Aug 1;23(15):4328-31. doi: 10.1016/j.bmcl.2013.05.093.
Kiyoshi Okada 1,  Yue Qi Ye,  Kayoko Taniguchi,  Ayaka Yoshida,  Tomonori Akiyama,  Yasukiyo Yoshioka,  Jun-ichi Onose,  Hiroyuki Koshino,  Shunya Takahashi,  Arata Yajima,  Naoki Abe,  Shunsuke Yajima
Affiliations

Affiliation

  • 1 Department of Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan.
PMID: 23791076 DOI: 10.1016/j.bmcl.2013.05.093
Abstract

Vialinin A, a small compound isolated from the Chinese mushroom Thelephora vialis, exhibits more effective anti-inflammatory activity than the widely used immunosuppressive drug tacrolimus (FK506). Here, we show that ubiquitin-specific peptidase 5/isopeptidase T (USP5/IsoT) is a target molecule of vialinin A, identified by using a beads-probe method. Vialinin A inhibited the peptidase activity of USP5/IsoT and also inhibited the enzymatic activities of USP4 among deubiquitinating Enzymes tested. Although USPs are a member of thiol protease family, vialinin A exhibited no inhibitions for Other thiol proteases, such as calpain and Cathepsin.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z