2. Academic Validation
  3. Guanidine alkaloids from Plumbago zeylanica

Guanidine alkaloids from Plumbago zeylanica

  • J Nat Prod. 2013 Jul 26;76(7):1351-7. doi: 10.1021/np400235s.
Hai-Jian Cong 1,  Shu-Wei Zhang,  Yu Shen,  Yong Zheng,  Yu-Jie Huang,  Wen-Qiong Wang,  Ying Leng,  Li-Jiang Xuan
Affiliations

Affiliation

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, People's Republic of China.
PMID: 23848163 DOI: 10.1021/np400235s
Abstract

Eleven new guanidine Alkaloids, plumbagines A-G (2-8) and plumbagosides A-D (9-12), as well as two known analogues (1, 13), were isolated from the aerial parts of Plumbago zeylanica. Their structures were elucidated by spectroscopic analyses including 1D and 2D NMR, MS, IR, and CD methods. The absolute configuration of 1 was determined by single-crystal X-ray diffraction of its derivative (1a).

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