2. Academic Validation
  3. Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens

Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens

  • J Nat Prod. 2013 Sep 27;76(9):1612-8. doi: 10.1021/np400287r.
Xia Liu 1,  Xing-Wei Yang,  Chao-Qun Chen,  Chun-Yan Wu,  Jing-Jing Zhang,  Jun-Zeng Ma,  Huan Wang,  Li-Xin Yang,  Gang Xu
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
PMID: 23957453 DOI: 10.1021/np400287r
Abstract

Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC₅₀ 5.8-17.9 μM) against the tested tumor cell lines.

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