2. Academic Validation
  3. Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

  • Bioorg Med Chem Lett. 2013 Oct 1;23(19):5264-6. doi: 10.1016/j.bmcl.2013.08.021.
Theerachart Leepasert 1,  Manochehr Shahabi,  Karem Shanab,  Eva Schirmer,  Wolfgang Holzer,  Helmut Spreitzer,  Babette Aicher,  Gilbert Müller,  Eckhard Günther
Affiliations

Affiliation

  • 1 Department of Drug and Natural Product Synthesis, University of Vienna, Vienna, Austria.
PMID: 23988351 DOI: 10.1016/j.bmcl.2013.08.021
Abstract

A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.

Keywords

Anticancer compounds.

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