2. Academic Validation
  3. Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia

Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia

  • J Nat Prod. 2013 Oct 25;76(10):1854-9. doi: 10.1021/np400379u.
Qiu-Fen Hu 1,  Bin Zhou,  Yan-Qing Ye,  Zhi-Yong Jiang,  Xiang-Zhong Huang,  Yin-Ke Li,  Gang Du,  Guang-Yu Yang,  Xue-Mei Gao
Affiliations

Affiliation

  • 1 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
PMID: 24063582 DOI: 10.1021/np400379u
Abstract

Eight new C-4-alkylated deoxybenzoins (1-8), three new diphenylethylenes (9-11), and five known diphenylethylenes were isolated from Arundina graminifolia. The structures of 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 9-11 are the first naturally occurring diphenylethylenes possessing a hydroxyethyl unit. Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five Cancer cell lines, with IC50 values ranging from 1.8 to 8.7 μM.

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