2. Academic Validation
  3. Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis

Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis

  • J Nat Prod. 2013 Oct 25;76(10):1916-22. doi: 10.1021/np400497f.
Chang Hwa Hwang 1,  Birgit U Jaki,  Larry L Klein,  David C Lankin,  James B McAlpine,  José G Napolitano,  Nicole A Fryling,  Scott G Franzblau,  Sang Hyun Cho,  Paul E Stamets,  Yuehong Wang,  Guido F Pauli
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
PMID: 24087924 DOI: 10.1021/np400497f
Abstract

An EtOH extract of the polypore mushroom Fomitopsis officinalis afforded two new naturally occurring chlorinated Coumarins, which were identified as the previously synthesized compounds 6-chloro-4-phenyl-2H-chromen-2-one (1) and ethyl 6-chloro-2-oxo-4-phenyl-2H-chromen-3-carboxylate (2). The structures of the two isolates were deduced by ab initio spectroscopic methods and confirmed by chemical synthesis. In addition, an analogue of each was synthesized as 7-chloro-4-phenyl-2H-chromen-2-one (3) and ethyl 7-chloro-2-oxo-4-phenyl-2H-chromen-3-carboxylate (4). All four compounds were characterized physicochemically, and their antimicrobial activity profiles revealed a narrow spectrum of activity with lowest MICs against the Mycobacterium tuberculosis complex.

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