2. Academic Validation
  3. Cytotoxic ent-kaurane diterpenoids from Salvia cavaleriei

Cytotoxic ent-kaurane diterpenoids from Salvia cavaleriei

  • J Nat Prod. 2013 Dec 27;76(12):2253-62. doi: 10.1021/np400600c.
Heng Zheng 1,  Qiong Chen,  Mengke Zhang,  Yongji Lai,  Liang Lei,  Penghua Shu,  Jinwen Zhang,  Yongbo Xue,  Zengwei Luo,  Yan Li,  Guangmin Yao,  Yonghui Zhang
Affiliations

Affiliation

  • 1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
PMID: 24256484 DOI: 10.1021/np400600c
Abstract

Fifteen new ent-kaurane Diterpenoids, compounds 1-15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole Plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compounds 1-15 were evaluated for their cytotoxicity against five human Cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line. Compounds 1-10, 12, 14, and 15 showed broad-spectrum cytotoxicity, with compounds 1, 3, 6-10, 12, and 15 exhibiting more potent cytotoxicity than the positive control, cis-platin, with IC50 values ranging from 0.65 to 6.4 μM.

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