2. Academic Validation
  3. Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus

Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus

  • J Nat Prod. 2014 Jan 24;77(1):70-8. doi: 10.1021/np4006822.
Willian J Andrioli 1,  Raphael Conti,  Magali J Araújo,  Riccardo Zanasi,  Bruno C Cavalcanti,  Viviane Manfrim,  Juliano S Toledo,  Daniele Tedesco,  Manoel O de Moraes,  Cláudia Pessoa,  Angela K Cruz,  Carlo Bertucci,  José Sabino,  Dhammika N P Nanayakkara,  Mônica T Pupo,  Jairo K Bastos
Affiliations

Affiliation

  • 1 Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo , 14040-903, Ribeirão Preto, SP, Brazil.
PMID: 24387625 DOI: 10.1021/np4006822
Abstract

Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays.

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