2. Academic Validation
  3. Biologically active eremophilane-type sesquiterpenes from Camarops sp., an endophytic fungus isolated from Alibertia macrophylla

Biologically active eremophilane-type sesquiterpenes from Camarops sp., an endophytic fungus isolated from Alibertia macrophylla

  • J Nat Prod. 2014 Mar 28;77(3):668-72. doi: 10.1021/np400825s.
Juliana R Gubiani 1,  Maria L Zeraik,  Camila M Oliveira,  Valdecir F Ximenes,  Cláudio R Nogueira,  Luiz M Fonseca,  Dulce H S Silva,  Vanderlan S Bolzani,  Angela R Araujo
Affiliations

Affiliation

  • 1 Departamento de Química Orgânica, NuBBE - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Química, Universidade Estadual Paulista , Rua Professor Francisco Degni, 55, 14800-900, Araraquara, São Paulo, Brazil.
PMID: 24588269 DOI: 10.1021/np400825s
Abstract

Two new eremophilane-type Sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known compounds xylarenones C (1) and D (2). The structures and relative configurations of 1-4 were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the Reactive Oxygen Species production, these Sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties.

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