2. Academic Validation
  3. Fluorescent analog of OSW-1 and its cellular localization

Fluorescent analog of OSW-1 and its cellular localization

  • Bioorg Med Chem Lett. 2014 Apr 1;24(7):1839-42. doi: 10.1016/j.bmcl.2014.02.009.
Rika Yamada 1,  Tomoya Takeshita 1,  Masato Hiraizumi 1,  Daisuke Shinohe 1,  Yoshihiro Ohta 1,  Kaori Sakurai 2
Affiliations

Affiliations

  • 1 Tokyo University of Agriculture and Technology, School of Engineering, Koganei-shi, Tokyo 184-8588, Japan.
  • 2 Tokyo University of Agriculture and Technology, School of Engineering, Koganei-shi, Tokyo 184-8588, Japan. Electronic address: sakuraik@cc.tuat.ac.jp.
PMID: 24613377 DOI: 10.1016/j.bmcl.2014.02.009
Abstract

OSW-1 is a steroidal saponin, which has emerged as an attractive Anticancer agent with highly Cancer cell selective activity. A fluorescent analog was prepared from the natural product to analyze its cellular uptake and localization. We found that the fluorescent analog is rapidly internalized into cells and is primarily distributed in endoplasmic reticulum and Golgi apparatus.

Keywords

Anticancer agent; Cellular localization; Cellular uptake; Fluorescent probe; Steroidal glycoside.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z