2. Academic Validation
  3. Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity

Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity

  • Bioorg Med Chem. 2014 Apr 1;22(7):2236-43. doi: 10.1016/j.bmc.2014.02.014.
Wael M Abdel-Mageed 1,  Soad A H Bayoumi 2,  Caixia Chen 3,  Christopher J Vavricka 3,  Li Li 4,  Ajamaluddin Malik 5,  Huanqin Dai 3,  Fuhang Song 3,  Luoqiang Wang 6,  Jingyu Zhang 3,  George F Gao 3,  Yali Lv 7,  Lihong Liu 7,  Xueting Liu 8,  Hanaa M Sayed 9,  Lixin Zhang 10
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China; Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  • 2 Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
  • 3 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
  • 4 Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.
  • 5 Protein Research Chair, Department of Biochemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
  • 6 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China; School of Life Sciences, Anhui University, Hefei 230601, PR China.
  • 7 Beijing Chao-Yang Hospital Affiliated with Beijing Capital Medical University, Beijing 100020, PR China.
  • 8 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: liuxueting_cn@hotmail.com.
  • 9 Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: hanaa.sayed@gmail.com.
  • 10 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: zhanglixin@im.ac.cn.
PMID: 24613627 DOI: 10.1016/j.bmc.2014.02.014
Abstract

The high mutation rate of RNA viruses has resulted in limitation of vaccine effectiveness and increased emergence of drug-resistant viruses. New effective antivirals are therefore needed to control of the highly mutative RNA viruses. The n-butanol fraction of the stem bark of Mangifera indica exhibited inhibitory activity against influenza neuraminidase (NA) and coxsackie virus 3C protease. Bioassay guided phytochemical study of M. indica stem bark afforded two new compounds including one benzophenone C-glycoside (4) and one xanthone dimer (7), together with eleven known compounds. The structures of these isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Anti-influenza and anti-coxsackie virus activities were evaluated by determining the inhibition of anti-influenza neuraminidase (NA) from pandemic A/RI/5+/1957 H2N2 influenza A virus and inhibition of coxsackie B3 virus 3C protease, respectively. The highest anti-influenza activity was observed for compounds 8 and 9 with IC50 values of 11.9 and 9.2μM, respectively. Compounds 8 and 9 were even more potent against coxsackie B3 virus 3C protease, with IC50 values of 1.1 and 2.0μM, respectively. Compounds 8 and 9 showed weak cytotoxic effect against human hepatocellular carcinoma and human epithelial carcinoma cell lines through MTT assay.

Keywords

Anacardiaceae; Benzophenone C-glucosides; Coxsackie protease inhibitors; Cytotoxic effect; Gallotannins; Mangifera indica; Mangiferin dimmer; Neuraminidase inhibitors; Xanthones.

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