2. Academic Validation
  3. Anti-inflammatory labdane diterpenoids from Lagopsis supina

Anti-inflammatory labdane diterpenoids from Lagopsis supina

  • J Nat Prod. 2014 Apr 25;77(4):1047-53. doi: 10.1021/np5001329.
Hui Li 1,  Man-Man Li,  Xiao-Qin Su,  Jing Sun,  Yu-Fan Gu,  Ke-Wu Zeng,  Qian Zhang,  Yun-Fang Zhao,  Daneel Ferreira,  Jordan K Zjawiony,  Jun Li,  Peng-Fei Tu
Affiliations

Affiliation

  • 1 Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
PMID: 24707938 DOI: 10.1021/np5001329
Abstract

Ten new labdane Diterpenoids, lagopsins A-H (1-3, 5, 7-10) and 15-epi-lagopsins C and D (4, 6), together with five known labdane Diterpenoids (11-15), were isolated from the whole Plants of Lagopsis supina. The absolute configuration of lagopsin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 7, 9, 13, and 15 exhibited moderate inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 values in the range 14.9-34.9 μM.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z