2. Academic Validation
  3. Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities

Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities

  • Bioorg Med Chem Lett. 2014 May 1;24(9):2159-62. doi: 10.1016/j.bmcl.2014.03.027.
Xiaoting Xu 1,  Hong Bai 2,  Ling Zhou 2,  Zhipeng Deng 2,  Hao Zhong 2,  Zhongyu Wu 2,  Qingqiang Yao 3
Affiliations

Affiliations

  • 1 Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
  • 2 Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
  • 3 Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China. Electronic address: yao_imm@163.com.
PMID: 24717151 DOI: 10.1016/j.bmcl.2014.03.027
Abstract

Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-β-d-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1-6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human Cancer cell lines, with IC50 values in the low microgram range.

Keywords

Cucurbitane triterpenoids; Cytotoxic activities; Hemsleya penxianensis.

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