2. Academic Validation
  3. Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

  • Eur J Med Chem. 2014 Jun 23:81:341-9. doi: 10.1016/j.ejmech.2014.05.009.
Kothanahally S Sharath Kumar 1,  Ananda Hanumappa 1,  Mahesh Hegde 1,  Kereyagalahally H Narasimhamurthy 1,  Sathees C Raghavan 2,  Kanchugarakoppal S Rangappa 3
Affiliations

Affiliations

  • 1 Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysore 570006, India.
  • 2 Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
  • 3 Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysore 570006, India. Electronic address: rangappaks@gmail.com.
PMID: 24852281 DOI: 10.1016/j.ejmech.2014.05.009
Abstract

The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR and mass spectral analysis. Compound methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate (5) displayed potent activity (IC509.71, 15.24 and 19.29 μM) against Nalm6, K562, Jurkat cells. Cell cycle analysis and mitochondrial membrane potential further confirmed that compound 5 is cytotoxic and able to induce cell death.

Keywords

Apoptosis; Chemotherapeutics; Cytotoxicity; Leukemia; Propylphosphonic anhydride (T(3)P(®)); Thiazolidinones.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z