2. Academic Validation
  3. Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

  • ACS Med Chem Lett. 2012 Jan 17;3(2):165-9. doi: 10.1021/ml2003058.
Huayun Deng 1,  Haibei Hu 1,  Shizhang Ling 1,  Ann M Ferrie 1,  Ye Fang 1
Affiliations

Affiliation

  • 1 Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.
PMID: 24900447 DOI: 10.1021/ml2003058
Abstract

We report the discovery and characterization of natural Phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural Phenols are divergent in their biased agonism.

Keywords

GPR35; biased agonism; ellagic acid; natural phenols.

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