2. Academic Validation
  3. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage

Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage

  • Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. doi: 10.1016/j.etap.2014.05.018.
Khadijeh Jamialahmadi 1,  Omid Arasteh 2,  Maryam Matbou Riahi 3,  Soghra Mehri 4,  Bamdad Riahi-Zanjani 5,  Gholamreza Karimi 6
Affiliations

Affiliations

  • 1 Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 2 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 3 Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 4 Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 5 Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 6 Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Karimig@mums.ac.ir.
PMID: 24959958 DOI: 10.1016/j.etap.2014.05.018
Abstract

Glucosamine (GlcN) is an important precursor in the biochemical synthesis of glycosylated proteins and lipids in human body. It gains importance because of its contribution to human health and its multiple biological and therapeutic effects. In this study, the in vitro oxidative hemolysis of rat erythrocyte was used as a model to study the potential protective effect of glucosamine hydrochloride against free radical-induced damage of biological membranes. Glucosamine hydrochloride exhibited dose-dependent DPPH antioxidant activity. Oxidative hemolysis and lipid/protein peroxidation of erythrocytes induced by a water-soluble free radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were significantly suppressed by GlcN in a time and dose dependent manner. GlcN also prevented the depletion of cytosolic antioxidant glutathione (GSH) in erythrocytes. These results indicated that glucosamine hydrochloride efficiently protected erythrocytes against free radicals and it could be recommended as a pharmaceutical supplement to alleviate oxidative stress.

Keywords

AAPH; Erythrocyte; Glucosamine; Hemolysis; Oxidative stress.

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