2. Academic Validation
  3. Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

  • Evid Based Complement Alternat Med. 2014;2014:580483. doi: 10.1155/2014/580483.
Ruiqi Sun 1,  Haiyan Jiang 2,  Wenjuan Zhang 3,  Kai Yang 3,  Chengfang Wang 4,  Li Fan 4,  Qing He 1,  Jiangbin Feng 4,  Shushan Du 3,  Zhiwei Deng 1,  Zhufeng Geng 1
Affiliations

Affiliations

  • 1 Analytic and Testing Center, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.
  • 2 College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning 116600, China.
  • 3 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
  • 4 Key Laboratory of Radiological Protection and Nuclear Emergency, Chinese Center for Disease Control and Prevention, Haidian District, Beijing 100875, China.
PMID: 24963327 DOI: 10.1155/2014/580483
Abstract

Nine Alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhernovine (1), nantenine (2), corytuberine (3), lagesianine A (4), and dihydrocryptopine (9) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC50 values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μ M, respectively.

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