2. Academic Validation
  3. Triterpene glycosides from red ginseng marc and their anti-inflammatory activities

Triterpene glycosides from red ginseng marc and their anti-inflammatory activities

  • Bioorg Med Chem Lett. 2014 Sep 1;24(17):4203-8. doi: 10.1016/j.bmcl.2014.07.042.
Ill-Min Chung 1,  Young-Ock Kim 2,  Mohammed Ali 3,  Seung-Hyun Kim 1,  Inmyoung Park 4,  Eun-Hye Kim 1,  Ye-Sul Yang 1,  Hye-Ran Park 5,  Eun-Suk Son 5,  Ateeque Ahmad 6
Affiliations

Affiliations

  • 1 Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 143-701, South Korea.
  • 2 Department of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, South Korea.
  • 3 Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
  • 4 Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609-735, South Korea.
  • 5 Department of Applied Biochemistry, College of Biomedical and Health Science, Konkuk University, Chungju 380-701, South Korea.
  • 6 Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 143-701, South Korea. Electronic address: ateeque97@gmail.com.
PMID: 25106885 DOI: 10.1016/j.bmcl.2014.07.042
Abstract

Three new triterpene glycosides ursan-3β,19α,22β-triol-3-O-β-D-glucopyranosyl (2'→1″)-β-D-glucopyranoside (1), ursan-3α,11β-diol-3-O-α-D-glucopyranosyl-(6'→1″)-α-D-glucopyranosyl-(6″→1‴)-α-D-glucopyranosyl-(6‴→1‴')-α-D-glucopyranoside (2) and lanost-5,24-dien-3β-ol-3-O-β-D-glucopyranosyl-(6'→1″)-β-D-glucopyranosyl-(6″→1‴)-β-D-glucopyranoside (3), together with one known compound were isolated and identified from the marc of red ginseng. Their structures were elucidated by spectroscopic data analysis. Compounds (1-3) were investigated for anti-inflammatory effects using the RAW 264.7 macrophage cell line. In the cell proliferation assay, lipopolysaccharide stimulation decreased cell proliferation of RAW 264.7 macrophage cells, but the suppression of cell proliferation was significantly protected by treatment with compounds 2 and 3. Compounds 2 and 3 had a suppressive effect on the production of nitric oxide (NO), and they inhibited mRNA expression of proinflammatory mediators such as inducible nitric oxide synthase, and cyclooxygenase-2, and proinflammatory cytokines such as two interleukins and tumor necrosis factor-α. These findings suggest that compounds 2 and 3 have potential anti-inflammatory activities.

Keywords

Antiinflammatory activity; Araliaceae; Panax ginseng; Triterpene glycosides.

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