2. Academic Validation
  3. Weakly anti-inflammatory limonoids from the seeds of Xylocarpus rumphii

Weakly anti-inflammatory limonoids from the seeds of Xylocarpus rumphii

  • J Nat Prod. 2014 Sep 26;77(9):2037-43. doi: 10.1021/np5003687.
Chanin Sarigaputi 1,  Damrong Sommit,  Thapong Teerawatananond,  Khanitha Pudhom
Affiliations

Affiliation

  • 1 Program in Biotechnology and §Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.
PMID: 25140384 DOI: 10.1021/np5003687
Abstract

Seven new limonoids, namely, xylorumphiins E-J (1-2 and 4-7) and 2-hydroxyxylorumphiin F (3), along with three known derivatives (8-10), were isolated from the seeds of Xylocarpus rumphii. 2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 μM, respectively.

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