2. Academic Validation
  3. Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia

Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia

  • Pharmacol Biochem Behav. 2014 Oct;125:70-77. doi: 10.1016/j.pbb.2014.08.007.
Mohammad Nasehi 1,  Mehdi Jamshidi-Mehr 2,  Fatemeh Khakpai 3,  Mohammad-Reza Zarrindast 4
Affiliations

Affiliations

  • 1 School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran. Electronic address: Nasehi@iricss.org.
  • 2 Department of Biology, Faculty of Basic Science, Tarbiat Moalem (Kharazmi) University, Tehran, Iran.
  • 3 Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
  • 4 School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Electronic address: zarinmr@ams.ac.ir.
PMID: 25181578 DOI: 10.1016/j.pbb.2014.08.007
Abstract

In the present study, effects of the serotonergic system of the dorsal hippocampus (CA1) on harmaline-induced amnesia were examined. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-peritoneal (i.p.) administration of harmaline (1mg/kg) induced impairment of memory retention. Moreover, intra-CA1 administration of 5-HT1B/1D receptor agonist, CP94253 (5 ng/mouse), 5-HT1B/1D receptor antagonist, GR127935 (0.05 and 0.5 ng/mouse), 5-HT2A/2B/2C receptor agonist, α-methyl 5-HT (0.5 ng/mouse) and 5-HT2 receptor antagonist, cinancerine (0.5 ng/mouse) impaired memory acquisition, but did not affect locomotor activity and tail flick. Furthermore, pre-training intra-CA1 injection of subthreshold dose of CP94253 (0.05 ng/mouse) or GR127935 (0.005 ng/mouse) reversed impairment of memory acquisition induced by harmaline (1 mg/kg, i.p.). However, pre-training intra-CA1 infusion of subthreshold dose of α-methyl 5-HT (0.005 ng/mouse) or cinancerine (0.005 ng/mouse) with the administration of harmaline (0.5 and 1 mg/kg, i.p.) heighten impairment of memory acquisition. These findings implicate the involvement of CA1 serotonergic mechanism in harmaline-induced impairment of memory acquisition.

Keywords

Harmaline; Memory; Mice; Passive avoidance; Serotonergic system.

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